Comprehensive analysis of DNA methylation for periodontitis.

ABSTRACT:

Background

Periodontitis is an infectious disease, and a risk factor for peri-implantitis that could result in the implant loss. DNA methylation has an essential role in the etiology and pathogenesis of inflammatory disease. However, there is lack of study on methylation status of genes in periodontitis. This study sought to explore the gene methylation profiling microarray in periodontitis.

Methods

Through searching in the Gene Expression Omnibus database, a gene methylation profiling data set GSE173081 was identified, which included 12 periodontitis samples and 12 normal samples, respectively. Thereafter, the data of GSE173081 was downloaded and analyzed to determined differentially methylated genes (DMGs), which then were used to perform Gene Ontology analysis and pathway

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC9058047 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature