ABSTRACT:

Objective

We examined weather a protocol for fraction of inspired oxygen (FiO₂) adjustment can reduce hyperoxemia and excess oxygen use in COVID-19 patients mechanically ventilated.

Design

Prospective cohort study.

Setting

Two intensive care units (ICUs) dedicated to COVID-19 patients in Brazil.

Patients

Consecutive patients with COVID-19 mechanically ventilated.

Interventions

One ICU followed a FiO₂ adjustment protocol based on SpO₂ (conservative-oxygen ICU) and the other, which did not follow the protocol, constituted the control ICU.

Main variables of interest

Pprevalence of hyperoxemia (PaO₂>100 mmHg) on day 1, sustained hyperoxemia (present on days 1 and 2), and excess oxygen use (FiO₂>0.

SUBMITTER: Gomes EP 

PROVIDER: S-EPMC9058051 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature