Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array.

ABSTRACT: Myelinated fibers are specialized neurological structures used for conducting action potentials quickly and reliably, thus assisting neural functions. Although demyelination leads to serious functional impairments, little is known the relationship between myelin structural change and increase in conduction velocity during myelination and demyelination processes. There are no appropriate methods for the long-term evaluation of spatial characteristics of saltatory conduction along myelinated axons. Herein, we aimed to detect saltatory conduction from the peripheral nervous system neurons using a high-density microelectrode array. Rat sensory neurons and intrinsic Schwann cells were cultured. Immunofluorescence and ultrastructure examination showed that the myelinating Schwann cells appeared

SUBMITTER: Shimba K 

PROVIDER: S-EPMC9058065 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature