Evaluation of Closed System Transfer Devices in Preventing Chemotherapy Agents Contamination During Compounding Process-A Single and Comparative Study in China.

ABSTRACT:

Aim

We performed a comparative study to investigate the efficacy of closed system transfer devices (CSTDs) on the safe handling of injectable hazardous drugs (HDs).

Methods

The exposure assessments of cyclophosphamide and cytarabine were performed under traditional or CSTDs. For preparation activity, chemotherapy contamination samples on protective equipment (such as gloves and masks) were collected. The contamination analysis was performed by liquid chromatography with tandem mass spectrometry (LC-MS/MS). A 6-item form was distributed monthly (form M1-M6, total 6 months) to assess the pharmacists' experience on ergonomics, encumbrance, and safety impression.

Results

Totally, 96 wiping samples were collected throughout the study. The numbers of contaminated cyclophosp

SUBMITTER: Tang Y 

PROVIDER: S-EPMC9058097 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature