Deciphering Risperidone-Induced Lipogenesis by Network Pharmacology and Molecular Validation.

ABSTRACT:

Background

Risperidone is an atypical antipsychotic that can cause substantial weight gain. The pharmacological targets and molecular mechanisms related to risperidone-induced lipogenesis (RIL) remain to be elucidated. Therefore, network pharmacology and further experimental validation were undertaken to explore the action mechanisms of RIL.

Methods

RILs were systematically analyzed by integrating multiple databases through integrated network pharmacology, transcriptomics, molecular docking, and molecular experiment analysis. The potential signaling pathways for RIL were identified and experimentally validated using gene ontology (GO) enrichment and Kyoto encyclopedia of genes and genomes (KEGG) analysis.

Results

Risperidone promotes adipocyte differentiation and lipi

SUBMITTER: Fu Y 

PROVIDER: S-EPMC9058120 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature