Cardiorespiratory Fitness Is Associated With Better White Matter Integrity in Persons Living With HIV.

ABSTRACT:

Background

Despite improved survival rates, neurocognitive impairment persists in persons living with HIV (PLWH). An active lifestyle is linked to improved cognition among PLWH, yet the neural substrates remain unclear. Diffusion tensor imaging and diffusion basis spectrum imaging measure HIV-related changes in brain white matter integrity. We used these measures of structural brain integrity to assess white matter changes, physical fitness, and cognition in a cross-sectional study of PLWH.

Methods

Forty-four virologically well-controlled PLWH were recruited (average age of 56 years, a median recent CD4+ count of 682 cells/mm3). Diffusion tensor imaging -derived fractional anisotropy (FA) and diffusion basis spectrum imaging-derived axonal density were calculated. Cardioresp

SUBMITTER: Kilgore CB 

PROVIDER: S-EPMC9058177 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature