Development of a reproducible porcine model of infected burn wounds.

ABSTRACT: Severe burns are traumatic and physically debilitating injuries with a high rate of mortality. Bacterial infections often complicate burn injuries, which presents unique challenges for wound management and improved patient outcomes. Currently, pigs are used as the gold standard of pre-clinical models to study infected skin wounds due to the similarity between porcine and human skin in terms of structure and immunological response. However, utilizing this large animal model for wound infection studies can be technically challenging and create issues with data reproducibility. We present a detailed protocol for a porcine model of infected burn wounds based on our experience in creating and evaluating full thickness burn wounds infected with Staphylococcus aureus on six pigs. Wound hea

SUBMITTER: Al-Deen Said S 

PROVIDER: S-EPMC9058257 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature