Folic acid-sulfonamide conjugates as antibacterial agents: design, synthesis and molecular docking studies.

ABSTRACT: Dihydrofolate reductase (DHFR) inhibitors, as antibacterial agents, contain pyrimidine, pteridine, and azine moieties among many other scaffolds. Folic acid (FA), with a pteridine ring and amine group, was used as our focus scaffold, which was then conjugated with sulfonamides to develop new conjugates. The novel synthesized conjugates were characterized using infrared spectroscopy, and ¹H and ¹³C nuclear magnetic resonance (NMR) spectral studies and consequently screened for antimicrobial activities against bacterial strains with ampicillin as a positive control. Compound DS2 has the highest zone of inhibition (36.6 mm) with a percentage activity index (%AI) value of 122.8% against S. aureus and a minimum inhibitory concentration (MIC) of 15.63 μg mL^-1

SUBMITTER: Shahzad S 

PROVIDER: S-EPMC9058261 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature