Increased activation of cGAS-STING pathway enhances radiosensitivity of non-small cell lung cancer cells.

ABSTRACT:

Background

Radiotherapy is an effective therapeutic approach widely used clinically in non-small cell lung cancer (NSCLC), but radioresistance remains a major challenge. New and effective radiosensitizing approaches are thus urgently needed. The activation of DNA-sensing cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has become an attractive therapeutic target, but the relationship between activation of cGAS-STING pathway and radiosensitization of NSCLC cells remains unknown.

Methods

Considering low expression of cGAS-STING pathway genes in NSCLC, including STING, we used an activator (STING agonist, dimeric amidobenzimidazole [diABZI]) of cGAS-STING pathway and increased activation factor (DNA double strand breaks) of cGAS-STING pathway to res

SUBMITTER: Xue A 

PROVIDER: S-EPMC9058302 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature