Cyclohexamer [-(d-Phe-azaPhe-Ala)₂-]: good candidate to formulate supramolecular organogels.

ABSTRACT: Molecular self-assembly is a fascinating process which has become an area of great interest in supramolecular chemistry, as it leads in certain cases to molecular gels. Organogels formulated from low molecular weight compounds (LMWOGs) have attracted much interest in the past decades due to their applications as new soft materials. Herein, we report on the ability of the cyclic pseudopeptide cyclo-[-(d-Phe-azaPhe-Ala)₂-] (2) to self-assemble in some aromatic solvents and to form organogels driven by non-covalent forces, mainly hydrogen bonding and π-stacking interactions. Comprehensive FTIR and NMR studies emphasized that this cyclic aza-peptide adopts a β-turn conformation at low concentration in toluene, while an equilibrium between the monomeric states (intramolecular forces)

SUBMITTER: Ibrahim MIA 

PROVIDER: S-EPMC9058333 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature