Influence of the physicochemical features of TiO₂ nanoparticles on the formation of a protein corona and impact on cytotoxicity.

ABSTRACT: Due to their unique properties TiO₂ nanoparticles are widely used. The adverse effects they may elicit are usually studied in relation to their physicochemical features. However, a factor is often neglected: the influence of the protein corona formed around nanoparticles upon contact with biological media. Indeed, although it is acknowledged that it can strongly influence nanoparticle toxicity, it is not systematically considered. The aim of this study was to characterize the formation of the protein corona of TiO₂ nanoparticles as a function of the main nanoparticle properties and investigate potential relationship with the cytotoxicity nanoparticles induce in vitro in human lung cells. To that purpose, five TiO₂ nanoparticles differing in size, sha

SUBMITTER: Kose O 

PROVIDER: S-EPMC9058407 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature