Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission.

ABSTRACT: Neural circuit function requires mechanisms for controlling neurotransmitter release and the activity of neuronal networks, including modulation by synaptic contacts, synaptic plasticity, and homeostatic scaling. However, how neurons intrinsically monitor and feedback control presynaptic neurotransmitter release and synaptic vesicle (SV) recycling to restrict neuronal network activity remains poorly understood at the molecular level. Here, we investigated the reciprocal interplay between neuronal endosomes, organelles of central importance for the function of synapses, and synaptic activity. We show that elevated neuronal activity represses the synthesis of endosomal lipid phosphatidylinositol 3-phosphate [PI(3)P] by the lipid kinase VPS34. Neuronal activity in turn is regulated by endosom

SUBMITTER: Liu GT 

PROVIDER: S-EPMC9058544 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature