Longitudinal evaluation of treatment patterns, risk factors and outcomes in patients with cardiovascular disease treated with lipid-lowering therapy in the UK.

ABSTRACT:

Objectives

To compare treatment patterns, risk factors and cardiovascular disease (CVD) event rates in the UK from 2008 to 2017.

Design

Retrospective cohort study using the Clinical Practice Research Datalink.

Setting

UK primary care.

Participants

We selected 10 annual cohorts of patients with documented CVD receiving lipid-lowering therapy and the subsets with myocardial infarction (MI). Each cohort included patients ≥18 years old, with ≥1 year of medical history and ≥2 lipid-lowering therapy prescriptions in the prior year.

Primary and secondary outcome measures

For each annual cohort, we identified cardiovascular risk factors and lipid-lowering therapy and estimated the 1-year composite rate of fatal and non-fatal MI, ischaemic stroke (IS) or revascul

SUBMITTER: Danese M 

PROVIDER: S-EPMC9058773 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature