Faecal calprotectin and rectal histological inflammatory markers in cystic fibrosis: a single-centre study.

ABSTRACT:

Objective

To analyse the association of faecal calprotectin with the genetic and clinical characteristics of paediatric patients with cystic fibrosis (PwCF). In a subset of these patients, we aimed to associate histological inflammatory features of rectal mucosa to faecal calprotectin levels.

Methods

In a prospective study, faecal calprotectin levels were collected in all 23 PwCF attending our paediatric centre, together with demographic and clinical data. Associations between faecal calprotectin and clinical features were determined. In 11 of these patients, endoscopic rectal biopsies were obtained and the association between faecal calprotectin and histological inflammatory markers was analysed. Statistical analyses included Spearman's correlation coefficient, Mann-Whitney

SUBMITTER: Roda J 

PROVIDER: S-EPMC9058793 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature