Neuroprotective effects of Korean White ginseng and Red ginseng in an ischemic stroke mouse model.

ABSTRACT:

Background

Stroke is a neurological disorder characterized by brain tissue damage following a decrease in oxygen supply to brain due to blocked blood vessels. Reportedly, 80% of all stroke cases are classified as cerebral infarction, and the incidence rate of this condition increases with age. Herein, we compared the efficacies of Korean White ginseng (WG) and Korean Red Ginseng (RG) extracts (WGex and RGex, respectively) in an ischemic stroke mouse model and confirmed the underlying mechanisms of action.

Methods

Mice were orally administered WGex or RGex 1 h before middle cerebral artery occlusion (MCAO), for 2 h; the size of the infarct area was measured 24 h after MCAO induction. Then, the neurological deficit score was evaluated and the efficacies of the two extracts wer

SUBMITTER: Jin M 

PROVIDER: S-EPMC9058837 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature