Mechanical Conflict-Avoidance Assay to Measure Pain Behavior in Mice.

ABSTRACT: Pain comprises of both sensory (nociceptive) and affective (unpleasant) dimensions. In preclinical models, pain has traditionally been assessed using reflexive tests that allow inferences regarding pain's nociceptive component but provide little information about the affective or motivational component of pain. Developing tests that capture these components of pain are therefore translationally important. Hence, researchers need to use non-reflexive behavioral assays to study pain perception at that level. Mechanical conflict-avoidance (MCA) is an established voluntary non-reflexive behavior assay, for studying motivational responses to a noxious mechanical stimulus in a 3 chamber paradigm. A change in a mouse's location preference, when faced with competing noxious stimuli, is used to inf

SUBMITTER: Gaffney CM 

PROVIDER: S-EPMC9058981 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature