Dataset Information

Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus.

ABSTRACT:

Objectives

To estimate the prevalence of cytomegalovirus (CMV) infections among newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda.

Design and methods

Three populations-newborn-mother pairs, neonates with sepsis, and infants (≤3 months) with nonpostinfectious (NPIH) or postinfectious (PIH) hydrocephalus-were evaluated for CMV infection at 3 medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV.

Results

The overall CMV prevalence in 2498 samples across all groups was 9%. In newborn-mother pairs, there was a 3% prevalence of cord blood CMV positivity and 33% prevalence of maternal vaginal shedding. In neonates with clinical sepsis, there was a 2% CMV prevalence. Maternal HIV seropositivity (adjusted odds ratio [aOR] 25.20; 95% confidence interval [CI] 4.43-134.26; p = 0.0001), residence in eastern Uganda (aOR 11.06; 95% CI 2.30-76.18; p = 0.003), maternal age <25 years (aOR 4.54; 95% CI 1.40-19.29; p = 0.02), and increasing neonatal age (aOR 1.08 for each day older; 95% CI 1.00-1.16; p = 0.05), were associated risk factors for CMV in neonates with clinical sepsis. We found a 2-fold higher maternal vaginal shedding in eastern (45%) vs western (22%) Uganda during parturition (n = 22/49 vs 11/50, the Fisher exact test; p = 0.02). In infants with PIH, the prevalence in blood was 24% and in infants with NPIH, it was 20%. CMV was present in the cerebrospinal fluid (CSF) of 13% of infants with PIH compared with 0.5% of infants with NPIH (n = 26/205 vs 1/194, p < 0.0001).

Conclusions

Our findings highlight that congenital and postnatal CMV prevalence is substantial in this African setting, and the long-term consequences are uncharacterized.

SUBMITTER: Hehnly C

PROVIDER: S-EPMC9058984 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus.

Hehnly Christine C Ssentongo Paddy P Bebell Lisa M LM Burgoine Kathy K Bazira Joel J Fronterre Claudio C Kumbakumba Elias E Mulondo Ronald R Mbabazi-Kabachelor Edith E Morton Sarah U SU Ngonzi Joseph J Ochora Moses M Olupot-Olupot Peter P Mugamba John J Onen Justin J Roberts Drucilla J DJ Sheldon Kathryn K Sinnar Shamim A SA Smith Jasmine J Ssenyonga Peter P Kiwanuka Julius J Paulson Joseph N JN Meier Frederick A FA Ericson Jessica E JE Broach James R JR Schiff Steven J SJ

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20220209

<h4>Objectives</h4>To estimate the prevalence of cytomegalovirus (CMV) infections among newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus in Uganda.<h4>Design and methods</h4>Three populations-newborn-mother pairs, neonates with sepsis, and infants (≤3 months) with nonpostinfectious (NPIH) or postinfectious (PIH) hydrocephalus-were evaluated for CMV infection at 3 medical centers in Uganda. Quantitative PCR (qPCR) was used to characterize the prevalence of CMV.<h4>Result ...[more]

PMID: 35150915

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Dataset Information

Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus.

Objectives

Design and methods

Results

Conclusions

Publications

Cytomegalovirus infections in infants in Uganda: Newborn-mother pairs, neonates with sepsis, and infants with hydrocephalus.

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