Effects of nebulized epinephrine in association with hypertonic saline for infants with acute bronchiolitis: A systematic review and meta-analysis.

ABSTRACT:

Background

Nebulized epinephrine and hypertonic saline have been extensively studied in infants with acute bronchiolitis, with conflicting results.

Aims

To evaluate the efficacy on length of stay (LOS), clinical severity scores (CSS), oxygen saturation (SaO₂), and safety profile of nebulized epinephrine plus hypertonic saline (HS) in infants with acute bronchiolitis.

Materials & methods

This is a systematic review and meta-analysis. Outcomes were represented by mean differences (MD) or standard mean differences (SMD) and 95% confidence intervals (CIs) were utilized.

Results

Eighteen trials were systematically selected and 16 of them contributed to the meta-analysis (1756 patients). Overall, a modest but significant positive impact was observed of the

SUBMITTER: Pereira RA 

PROVIDER: S-EPMC9059211 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature