The steroid hormone estriol (E₃) regulates epigenetic programming of fetal mouse brain and reproductive tract.

ABSTRACT:

Background

Estriol (E₃) is a steroid hormone formed only during pregnancy in primates including humans. Although E₃ is synthesized at large amounts through a complex pathway involving the fetus and placenta, it is not required for the maintenance of pregnancy and has classically been considered virtually inactive due to associated very weak canonical estrogen signaling. However, estrogen exposure during pregnancy may have an effect on organs both within and outside the reproductive system, and compounds with binding affinity for estrogen receptors weaker than E₃ have been found to impact reproductive organs and the brain. Here, we explore potential effects of E₃ on fetal development using mouse as a model system.

Results

We adminis

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC9059368 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature