Impact of a ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients.

ABSTRACT:

Purpose

Patients with head and neck cancer (HNC) are at risk of malnutrition, especially during radiochemotherapy. We aimed to study the impact of a ketogenic diet (KD) versus an unspecified standard diet (SD) on body composition and survival in HNC patients undergoing radio(chemo)therapy.

Methods

As part of a controlled clinical trial, non-metastasized HNC patients were enrolled into either a KD (N = 11) or an SD (N = 21) group between May 2015 and May 2021. Body composition was measured weekly by bioimpedance analysis and analyzed using linear mixed effects models. Overall and progression-free survival was assessed during regular follow-up.

Results

A total of 7 KD and 21 SD patients completed the study and were eligible for comparative analysis. Chemotherapy was sig

SUBMITTER: Klement RJ 

PROVIDER: S-EPMC9059453 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature