Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis.

ABSTRACT: Type 1 diabetes mellitus (T1DM) affects 9.5% of the population. T1DM is characterized by severe insulin deficiency that causes hyperglycemia and leads to several systemic effects. T1DM has been suggested as a risk factor for articular cartilage damage and loss, which could expedite the development of osteoarthritis (OA). OA represents a major public health challenge by affecting 300 million people globally, yet very little is known about the correlation between T1DM and OA. In addition, current studies that have looked at the interaction between diabetes mellitus and OA have reported conflicting results with some suggesting a positive correlation whereas others did not. In this study, we aimed to evaluate whether T1DM exacerbates the development of spontaneous OA or accelerates the progres

SUBMITTER: Rios-Arce ND 

PROVIDER: S-EPMC9059474 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature