BoneMA-synthesis and characterization of a methacrylated bone-derived hydrogel for bioprinting ofin-vitrovascularized tissue constructs.

ABSTRACT: It has long been proposed that recapitulating the extracellular matrix (ECM) of native human tissues in the laboratory may enhance the regenerative capacity of engineered scaffoldsin-vivo. Organ- and tissue-derived decellularized ECM biomaterials have been widely used for tissue repair, especially due to their intrinsic biochemical cues that can facilitate repair and regeneration. The main purpose of this study was to synthesize a new photocrosslinkable human bone-derived ECM hydrogel for bioprinting of vascularized scaffolds. To that end, we demineralized and decellularized human bone fragments to obtain a bone matrix, which was further processed and functionalized with methacrylate groups to form a photocrosslinkable methacrylate bone ECM hydrogel- bone-derived biomaterial (BoneMA

SUBMITTER: Parthiban SP 

PROVIDER: S-EPMC9059555 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature