High Insulin in Early Childhood Is Associated with Subsequent Asthma Risk Independent of Body Mass Index.

ABSTRACT:

Background

Asthma and obesity are major, interconnected public health challenges that usually have their origins in childhood, and for which the relationship is strengthened among those with insulin resistance.

Objective

To determine whether high insulin in early life confers increased longitudinal risk for asthma independent of body mass index.

Methods

The study used data from the Tucson Children's Respiratory Study (TCRS) and the Avon Longitudinal Study of Parents and Children (ALSPAC). Nonfasting insulin was measured in TCRS participants at age 6 years and fasting insulin in ALSPAC participants at age 8 years. Physician-diagnosed active asthma was determined at baseline and at subsequent assessments up to age 36 years in TCRS and 17 years in ALSPAC.

Results

SUBMITTER: Carr TF 

PROVIDER: S-EPMC9059620 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature