Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines.

ABSTRACT: A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.

SUBMITTER: Rzhevskiy SA 

PROVIDER: S-EPMC9059645 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature