No significant elevation of translocator protein binding in the brains of recently abstinent methamphetamine users.

ABSTRACT:

Background

Radioligands for the translocator protein (TSPO) 18 kDa have been used with positron emission tomography (PET) to assess neuroinflammation and microglial activation in psychiatric disorders. One study using this approach showed substantial TSPO elevation throughout the brain in chronic methamphetamine users following long-term abstinence (0.5-4 years), but clients typically present for treatment earlier in abstinence.

Methods

We used PET with [¹¹C]DAA1106 to compare standardized uptake values (SUVs) as an index of TSPO binding in the brains of methamphetamine-dependent participants who were abstinent for < 6 months (n = 11) and healthy controls (n = 12). We also assayed other typical correlates of Methamphetamine Dependence (e.g., striatal D2-type dopam

SUBMITTER: London ED 

PROVIDER: S-EPMC9059651 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature