Exclusive enteral nutrition remodels the intestinal flora in patients with active Crohn's disease.

ABSTRACT:

Background

Although there are many hypotheses, the pathogenesis of Crohn's disease (CD) is not completely clear so far. Exclusive enteral nutrition (EEN) is a routine measure in the treatment of active CD. We aimed at investigating the impact of EEN on patients with active CD from microbial metabolomics.

Methods

16S-rDNA sequencing technology and gas chromatography-mass spectrometer analysis were employed to investigate the modification of the intestinal flora and fecal short-chain fatty acid (SCFA) during the EEN.

Results

Seven patients with CD, who conducted EEN, were followed up successfully in the present study. The 8-week EEN resulted in a remission of the condition of subjects with active CD, as revealed by a significant decrease in erythrocyte sedimentation rat

SUBMITTER: Jiang J 

PROVIDER: S-EPMC9059691 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature