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DNA-affibody nanoparticle delivery system for cisplatin-based breast cancer chemotherapy.

ABSTRACT: Cisplatin is the most widely used anticancer drug, but its side effects limit the maximum systemic dose. To circumvent the side effects, a DNA tetrahedron-affibody nanoparticle was prepared by combination of a DNA chain with cisplatin via interstrand crosslinks or adducts. Each nanocarrier can bind ∼68 molecules of cisplatin. This cisplatin nanoparticle exhibited high selectivity and inhibition for breast cancer HER2 overexpressing cells BT474 and lower toxicity in MCF-7 cells with low HER2 expression. The nano-drug inhibited the growth of BT474 cells by 94.57% at 512 nM (containing 33.3 μM cisplatin), which was higher than that of cisplatin (82.9%, 33.3 μM).

SUBMITTER: Zhang C

PROVIDER: S-EPMC9059769 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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DNA-affibody nanoparticle delivery system for cisplatin-based breast cancer chemotherapy.

Zhang Chao C Zhang HongLei H Han MengNan M Yang XueLi X Pei ChaoHong C Xu ZhiDong Z Du Jie J Li Wei W Chen Shengxi S

RSC advances 20190115 4

Cisplatin is the most widely used anticancer drug, but its side effects limit the maximum systemic dose. To circumvent the side effects, a DNA tetrahedron-affibody nanoparticle was prepared by combination of a DNA chain with cisplatin <i>via</i> interstrand crosslinks or adducts. Each nanocarrier can bind ∼68 molecules of cisplatin. This cisplatin nanoparticle exhibited high selectivity and inhibition for breast cancer HER2 overexpressing cells BT474 and lower toxicity in MCF-7 cells with low HE ...[more]

PMID: 35516156

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