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Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran.

ABSTRACT: An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived "green" solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour^-1.

SUBMITTER: Zhang CT

PROVIDER: S-EPMC9059842 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran.

Zhang Chuan-Tao CT Zhu Rui R Wang Zheng Z Ma Bing B Zajac Adrian A Smiglak Marcin M Xia Chun-Nian CN Castle Steven L SL Wang Wen-Long WL

RSC advances 20190117 4

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived "green" solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour<sup>-1</sup>. ...[more]

PMID: 35516141

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