Thermoresponsive 2-hydroxy-3-isopropoxypropyl hydroxyethyl cellulose with tunable LCST for drug delivery.

ABSTRACT: Thermoresponsive polymer 2-hydroxy-3-isopropoxypropyl hydroxyethyl celluloses (HIPECs) were successfully synthesized, characterized, and applied for thermoresponsive drug delivery. The lower critical solution temperature (LCST) of HIPEC could be easily tuned from 21.1 to 56.1 °C as the molar substitution (MS) increased from 1.21 to 2.88. Dynamic light scattering and transmission electron microscopy experiments revealed that HIPEC can self-assemble into nano-sized aggregates, and their size could be changed by variation in temperature. Additionally, the critical aggregation concentration (CAC) ranged from 0.101 to 0.805 g L^-1 by changing MS of HIPEC. In vitro drug delivery studies indicated that the amphotericin B (AmpB) release rate was much faster at temperatures above L

SUBMITTER: Tian Y 

PROVIDER: S-EPMC9059852 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature