The clinical features and estimated incidence of MIS-C in Cape Town, South Africa.

ABSTRACT:

Background

Multisystem inflammatory syndrome is a severe manifestation of SARS-CoV-2 in children. The incidence of MIS-C after infection is poorly understood. There are very few cohorts describing MIS-C in Africa despite MIS-C being more common in Black children worldwide.

Methods

A cohort of children with MIS-C and healthy children was recruited from May 2020 until May 2021 from the two main paediatric hospitals in Cape Town, South Africa. Clinical and demographic data were collected, and serum was tested for SARS-CoV-2 antibodies. The incidence of MIS-C was calculated using an estimation of population exposure from seroprevalence in the healthy group. Summary data, non-parametric comparisons and logistic regression analyses were performed.

Results

Sixty eight childr

SUBMITTER: Butters C 

PROVIDER: S-EPMC9059902 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature