One step DNA amplification of mammalian cells in picoliter microwell arrays.

ABSTRACT: We developed a strategy for direct DNA amplification of single cells on a PEG-modified silica chip with 30 600 picoliter-sized microwells. HPV-positive cells in heterogeneous populations were successfully detected with high accuracy sensitivity as high as single copy.

SUBMITTER: Liu W 

PROVIDER: S-EPMC9059946 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature