Dual-hormone artificial pancreas for management of type 1 diabetes: Recent progress and future directions.

ABSTRACT: Over the last few years, technological advances have led to tremendous improvement in the management of type 1 diabetes (T1D). Artificial pancreas systems have been shown to improve glucose control compared with conventional insulin pump therapy. However, clinically significant hypoglycemic and hyperglycemic episodes still occur with the artificial pancreas. Postprandial glucose excursions and exercise-induced hypoglycemia represent major hurdles in improving glucose control and glucose variability in many patients with T1D. In this regard, dual-hormone artificial pancreas systems delivering other hormones in addition to insulin (glucagon or amylin) may better reproduce the physiology of the endocrine pancreas and have been suggested as an alternative tool to overcome these limitations in

SUBMITTER: Infante M 

PROVIDER: S-EPMC9059950 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature