Impact of visit-to-visit fasting plasma glucose variability on the development of diabetes: The mediation by insulin resistance.

ABSTRACT:

Background

Little is known about the risk of diabetes due to higher glycemic variability and the underlying mechanisms. We aimed to examine the association of visit-to-visit variability (VVV) in fasting plasma glucose (FPG) with incident diabetes in Chinese adults and whether the association was mediated by changes in insulin resistance (IR).

Methods

We included 1856 community residents without a history of diabetes and having attended 3 examinations in 2008, 2009, and 2013 respectively. The SD, the average successive variability (ASV), the coefficient of variation (CV), and the variability independent of the mean (VIM) of three recorded FPG measurements were calculated for each participant, and SD, ASV, CV, and VIM were used as a measure of VVV in FPG. Incident diabetes was

SUBMITTER: Xu J 

PROVIDER: S-EPMC9060060 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature