Effect of topical treatment with 7.5% urea in Ichthyosis Vulgaris: A randomized, controlled, double blinded, split body study evaluating the effect of urea cream compared to the vehicle (moisturizing) cream.

ABSTRACT:

Background

Ichthyosis Vulgaris (IV) is a common genetic skin disease, characterized by dry, scaling skin and itch. Urea cream has been a central part of IV treatment for decades, but only few studies have evaluated the effect of urea compared to basic moisturizers.

Objective

To evaluate the treatment effect of 7.5% urea cream compared to a basic moisturizer in patients with IV.

Methods

Participants (n = 14) were randomized to apply the 7.5% urea cream on one body half and a basic moisturizer on the other during a study period of 4 weeks. Measuring points on participants arms and legs were evaluated at baseline and at endpoint with a patient questionnaire visual assessment scale (VAS), a clinical scoring, and electronic skin hydration analysis to assess the trea

SUBMITTER: Dorf ILH 

PROVIDER: S-EPMC9060062 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature