Vitamin D receptor methylation attenuates the association between physical activity and type 2 diabetes mellitus: A case-control study.

ABSTRACT:

Background

Physical activity and vitamin D receptor (VDR) have been associated with type 2 diabetes mellitus (T2DM). However, the associations of VDR methylation with T2DM and physical activity remained unknown. We aimed to investigate whether VDR methylation was a link between physical activity and T2DM.

Methods

A 1:1 matching case-control study was designed based on the Henan Rural Cohort Study, including 272 pairs of T2DM patients and nonpatients. Physical activity level was assessed using the International Physical Activity Questionnaire. The high-resolution melt method was applied to determine the methylation level of the promoter region of VDR. The association between physical activity and T2DM was analyzed with a conditional logistic regression model. The effect modif

SUBMITTER: Yu S 

PROVIDER: S-EPMC9060074 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature