Experimental and theoretical evaluation on the antioxidant activity of a copper(ii) complex based on lidocaine and ibuprofen amide-phenanthroline agents.

ABSTRACT: A new copper(ii) complex, [Cu(LC)(Ibu-phen)(H₂O)₂](ClO₄)₂ (LC: lidocaine, Ibu-phen: ibuprofen amide-phenanthroline), was synthesized and characterized. The antioxidant activities of the free ligands and the copper(ii) complex were evaluated by in vitro experiments and theoretical calculations using density functional theory (DFT). Structures of the ligand Ibu-phen and the complex were identified by ¹H and ¹³C NMR, FT-IR spectroscopies, mass spectrometry, thermogravimetric analysis and elemental analysis. The antioxidant potentials of LC and Ibu-phen ligands as well as copper(ii) complex were also evaluated by DPPH˙, ABTS˙⁺, HO˙ essays and EPR spectroscopy. The experimental results show that the radical scav

SUBMITTER: Tabrizi L 

PROVIDER: S-EPMC9060296 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature