Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study.

ABSTRACT:

Background

A global stockpile of oral cholera vaccine (OCV) was established in 2013 for use in outbreak response and are licensed as two-dose regimens. Vaccine availability, however, remains limited. Previous studies have found that a single dose of OCV may provide substantial protection against cholera.

Methods

Using a mathematical model with two age groups paired with optimization algorithms, we determine the optimal vaccination strategy with one and two doses of vaccine to minimize cumulative overall infections, symptomatic infections, and deaths. We explore counterfactual vaccination scenarios in three distinct settings: Maela, the largest refugee camp in Thailand, with high in- and out-migration; N'Djamena, Chad, a densely populated region; and Haiti, where departments

SUBMITTER: Leung T 

PROVIDER: S-EPMC9060364 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature