Ontology highlight
ABSTRACT:
SUBMITTER: Zhang M
PROVIDER: S-EPMC9060427 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zhang Man M Xiong Xinnuo X Suo Zili Z Hou Quan Q Gan Na N Tang Peixiao P Ding Xiaohui X Li Hui H
RSC advances 20190129 7
The preparation of co-amorphous drug systems by adding a small molecular excipient is a promising formulation in the modern pharmaceutical industry to improve the solubility, dissolution rate, and bioavailability of poorly soluble drugs. In this study, palbociclib co-amorphous systems with organic acids (succinic, tartaric, citric, and malic acid) at molar ratios of 1 : 1 were prepared by co-milling and characterized by differential scanning calorimetry (DSC), fourier transform infrared spectros ...[more]