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A single-shot vaccine approach for the universal influenza A vaccine candidate M2e.

ABSTRACT: SignificanceAlthough the need for a universal influenza vaccine has long been recognized, only a handful of candidates have been identified so far, with even fewer advancing in the clinical pipeline. The 24-amino acid ectodomain of M2 protein (M2e) has been developed over the past two decades. However, M2e-based vaccine candidates have shortcomings, including the need for several administrations and the lack of sustained antibody titers over time. We report here a vaccine targeting strategy that has the potential to confer sustained and strong protection upon a single shot of a small amount of M2e antigen. The current COVID-19 pandemic has highlighted the importance of developing versatile, powerful platforms for the rapid deployment of vaccines against any incoming threat.

SUBMITTER: Kavishna R

PROVIDER: S-EPMC9060463 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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A single-shot vaccine approach for the universal influenza A vaccine candidate M2e.

Kavishna Ranmali R Kang Tha Yang TY Vacca Maurizio M Chua Benson Yen Leong BYL Park Hae-Young HY Tan Peck Szee PS Chow Vincent Tk VT Lahoud Mireille H MH Alonso Sylvie S

Proceedings of the National Academy of Sciences of the United States of America 20220323 13

SignificanceAlthough the need for a universal influenza vaccine has long been recognized, only a handful of candidates have been identified so far, with even fewer advancing in the clinical pipeline. The 24-amino acid ectodomain of M2 protein (M2e) has been developed over the past two decades. However, M2e-based vaccine candidates have shortcomings, including the need for several administrations and the lack of sustained antibody titers over time. We report here a vaccine targeting strategy that ...[more]

PMID: 35320040

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