Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis.

ABSTRACT: Neural stem cells, the source of newborn neurons in the adult hippocampus, are intimately involved in learning and memory, mood, and stress response. Despite considerable progress in understanding the biology of neural stem cells and neurogenesis, regulating the neural stem cell population precisely has remained elusive because we have lacked the specific targets to stimulate their proliferation and neurogenesis. The orphan nuclear receptor TLX/NR2E1 governs neural stem and progenitor cell self-renewal and proliferation, but the precise mechanism by which it accomplishes this is not well understood because its endogenous ligand is not known. Here, we identify oleic acid (18:1ω9 monounsaturated fatty acid) as such a ligand. We first show that oleic acid is critical for neural stem cell surv

SUBMITTER: Kandel P 

PROVIDER: S-EPMC9060471 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature