IGFBP-3 functions as a molecular switch that mediates mitochondrial and metabolic homeostasis.

ABSTRACT: Mitochondrial dysfunction or loss of homeostasis is a central hallmark of many human diseases. Mitochondrial homeostasis is mediated by multiple quality control mechanisms including mitophagy, a form of selective autophagy that recycles terminally ill or dysfunctional mitochondria in order to preserve mitochondrial integrity. Our prior studies have shown that members of the insulin-like growth factor (IGF) family localize to the mitochondria and may play important roles in mediating mitochondrial health in the corneal epithelium, an integral tissue that is required for the maintenance of optical transparency and vision. Importantly, the IGF-binding protein-3, IGFBP-3, is secreted by corneal epithelial cells in response to stress and functions to mediate intracellular receptor trafficking i

SUBMITTER: Stuard WL 

PROVIDER: S-EPMC9060658 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature