Novel chalcone derivatives containing a 1,2,4-triazine moiety: design, synthesis, antibacterial and antiviral activities.

ABSTRACT: A series of novel chalcone derivatives containing the 1,2,4-triazine moiety were synthesized and their structures were confirmed by ¹H NMR, ¹³C NMR and elemental analyses. Antiviral bioassays revealed that most of the compounds exhibited good antiviral activity against tobacco mosaic virus (TMV) at a concentration of 500 μg mL^-1. The designated compound 4l was 50% effective in terms of curative and protective activities against TMV with 50% effective concentrations (EC₅₀) of 10.9 and 79.4 μg mL^-1, which were better than those of ningnanmycin (81.4 and 82.2 μg mL^-1). Microscale thermophoresis (MST) also showed that the binding of compound 4l to coat protein (TMV-CP) yielded a K _d value of 0.275 ± 0.160 μmol

SUBMITTER: Tang X 

PROVIDER: S-EPMC9060900 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature