Rules of Chinese Herbal Intervention of Radiation Pneumonia Based on Network Pharmacology and Data Mining.

ABSTRACT:

Objective

To explore the mechanism and principles of traditional Chinese medicine (TCM) in the management of radiation pneumonia.

Methods

The targets of radiation pneumonia were obtained by screening the GeneCards, OMIM, TTD, DrugBank, and HERB databases, analyzing ADME parameters. In addition, compounds and Chinese herbs that can act on the targets were screened from the TCMSP database. The core target compounds for TCM were used to construct the target-compound, compound-traditional Chinese medicine, and target-compound-traditional Chinese medicine networks. These networks were further used to select the core targets, compounds, and TCM. The binding strength between the core targets and compounds was determined using AutoDock Vina. The trajectory for the molecular dynamics

SUBMITTER: Dan W 

PROVIDER: S-EPMC9060976 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature