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Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe.

ABSTRACT: A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO^-) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO^- in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO^- in vivo.

SUBMITTER: Ma Y

PROVIDER: S-EPMC9061049 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe.

Ma Ying Y Tian Haigang H Jin Zhengyu Z Li Xiaoyong X Li Yiping Y

RSC advances 20190225 12

A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO-) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO- in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO- in vivo. ...[more]

PMID: 35518452

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