Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe.

ABSTRACT: A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO^-) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO^- in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO^- in vivo.

SUBMITTER: Ma Y 

PROVIDER: S-EPMC9061049 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature