Are lipid nanoparticles really superior? A holistic proof of concept study.

ABSTRACT: Lipid nanoparticles are a successful carrier system for dermal drug delivery. They possess various beneficial properties, i.e., increased chemical stability for chemically labile compounds, increased dermal penetration of active compounds, or skin carrying properties after dermal application due to the formation of a so-called "invisible patch." Despite manifold studies showing these properties individually, a study that investigates if one lipid nanoparticle formulation can really combine all the above-mentioned benefits at once is not yet available. In the present study, lipid nanoparticles (NLC) were produced and characterized regarding their physico-chemical properties. The chemical stability of the incorporated active ingredient (AI) was determined, as well as the dermal penetration e

SUBMITTER: Wiemann S 

PROVIDER: S-EPMC9061673 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature