Ontology highlight
ABSTRACT:
SUBMITTER: Saito Y
PROVIDER: S-EPMC9061724 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Saito Yasuhiro Y Matsuda Shiori S Ohnishi Naomi N Endo Keiko K Ashitani Sanae S Ohishi Maki M Ueno Ayano A Tomita Masaru M Ueda Koji K Soga Tomoyoshi T Muthuswamy Senthil K SK
Communications biology 20220502 1
Estrogen receptor (ER) positive breast cancer represents 75% of all breast cancers in women. Although patients with ER+ cancers receive endocrine therapies, more than 30% develop resistance and succumb to the disease, highlighting the need to understand endocrine resistance. Here we show an unexpected role for the cell polarity protein SCRIB as a tumor-promoter and a regulator of endocrine resistance in ER-positive breast cancer cells. SCRIB expression is induced by estrogen signaling in a MYC-d ...[more]