A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony.

ABSTRACT: Plasmodium sporozoites invade hepatocytes and transform into liver stages within a parasitophorous vacuole (PV). The parasites then grow and replicate their genome to form exoerythrocytic merozoites that infect red blood cells. We report that the human malaria parasite Plasmodium falciparum (Pf) expresses a C-type ATP-binding cassette transporter, Pf ABCC2, which marks the transition from invasive sporozoite to intrahepatocytic early liver stage. Using a humanized mouse infection model, we show that Pf ABCC2 localizes to the parasite plasma membrane in early and mid-liver stage parasites but is not detectable in late liver stages. Pf abcc2 ^- sporozoites invade hepatocytes, form a PV, and transform into liver stage trophozoites but cannot

SUBMITTER: Goswami D 

PROVIDER: S-EPMC9061783 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature