A ratiometric fluorescent probe for detection of exogenous mitochondrial SO₂ based on a FRET mechanism.

ABSTRACT: A novel imidazo[1,5-a]pyridine-hemicyanine based ratiometric fluorescent probe for detection of mitochondrial SO₂ was designed and synthesized. The probe is based on a fluorescence resonance energy transfer (FRET) mechanism. It exhibits high selectivity and sensitivity towards SO₃ ^2- with a fast response time (3 min) and detection limit of 0.13 μM. Further, it showed low cytotoxicity and was successfully applied to image exogenous mitochondrial SO₂ in cells.

SUBMITTER: Xu Z 

PROVIDER: S-EPMC9062019 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature