Extensive Chromatin Structure-Function Associations Revealed by Accurate 3D Compartmentalization Characterization.

ABSTRACT: A/B compartments are observed in Hi-C data and coincide with eu/hetero-chromatin. However, many genomic regions are ambiguous under A/B compartment scheme. We develop MOSAIC (MOdularity and Singular vAlue decomposition-based Identification of Compartments), an accurate compartmental state detection scheme. MOSAIC reveals that those ambiguous regions segregate into two additional compartmental states, which typically correspond to short genomic regions flanked by long canonical A/B compartments with opposite activities. They are denoted as micro-compartments accordingly. In contrast to the canonical A/B compartments, micro-compartments cover ∼30% of the genome and are highly dynamic across cell types. More importantly, distinguishing the micro-compartments underpins accurate characterizatio

SUBMITTER: Wen Z 

PROVIDER: S-EPMC9062080 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature