Ontology highlight
ABSTRACT:
SUBMITTER: Huang S
PROVIDER: S-EPMC9062088 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Huang Shenzhen S Wang Xiang X Lin Guifeng G Cheng Jie J Chen Xiuli X Sun Weining W Xiang Rong R Yu Yamei Y Li Linli L Yang Shengyong S
RSC advances 20190322 16
The human tyrosyl transfer-RNA (tRNA) synthetase (TyrRS), which is well known for its essential aminoacylation function in protein synthesis, has been shown to translocate to the nucleus and protect against DNA damage caused by external stimuli. Small molecules that can fit into the active site pocket of TyrRS are thought to affect the nuclear role. The exploitation of TyrRS inhibitors has attracted attention recently. In this investigation, we adopted a structure-based virtual screening strateg ...[more]